Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosis
PL Carmichael, A Hewer, MR Osborne, AJ Strain… - Mutation Research …, 1995 - Elsevier
In the human metal storage disorders of Wilson's disease and primary haemochromatosis,
ion transport and excretion dysfunctions result in the intracellular deposition of copper and
iron, respectively. These aberrant accumulations of transition metal ions lead to extensive
tissue damage, especially in the liver. In order to investigate the possible role of metal ion-
mediated oxygen free radical-generated DNA damage in these processes, DNA was
isolated from liver of eight Wilson's disease patients and six haemochromatosis patients …
ion transport and excretion dysfunctions result in the intracellular deposition of copper and
iron, respectively. These aberrant accumulations of transition metal ions lead to extensive
tissue damage, especially in the liver. In order to investigate the possible role of metal ion-
mediated oxygen free radical-generated DNA damage in these processes, DNA was
isolated from liver of eight Wilson's disease patients and six haemochromatosis patients …
