[HTML][HTML] Intracerebroventricular delivery as a safe, long-term route of drug administration
JL Cohen-Pfeffer, S Gururangan, T Lester, DA Lim… - Pediatric …, 2017 - Elsevier
Intrathecal delivery methods have been used for many decades to treat a broad range of
central nervous system disorders. A literature review demonstrated that
intracerebroventricular route is an established and well-tolerated method for prolonged
central nervous system drug delivery in pediatric and adult populations.
Intracerebroventricular devices were present in patients from one to 7156 days. The number
of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient …
central nervous system disorders. A literature review demonstrated that
intracerebroventricular route is an established and well-tolerated method for prolonged
central nervous system drug delivery in pediatric and adult populations.
Intracerebroventricular devices were present in patients from one to 7156 days. The number
of punctures per device ranged from 2 to 280. Noninfectious complication rates per patient …
