Known therapies for influenza A virus infection are complicated by the frequent emergence
of resistance. A therapeutic strategy that may escape viral resistance is targeting host
cellular mechanisms involved in viral replication and pathogenesis. The endoplasmic
reticulum (ER) stress response, also known as the unfolded protein response (UPR), is a
primitive, evolutionary conserved molecular signaling cascade that has been implicated in
multiple biological phenomena including innate immunity and the pathogenesis of certain …