[HTML][HTML] Redox regulation of epithelial sodium channels examined in alveolar type 1 and 2 cells patch-clamped in lung slice tissue
The alveolar surface of the lung is lined by alveolar type 1 (AT1) and type 2 (AT2) cells.
Using single channel patch clamp analysis in lung slice preparations, we are able to
uniquely study AT1 and AT2 cells separately from intact lung. We report for the first time the
Na+ transport properties of type 2 cells accessed in live lung tissue (as we have done in type
1 cells). Type 2 cells in lung tissue slices express both highly selective cation and
nonselective cation channels with average conductances of 8.8±3.2 and 22.5±6.3 …
Using single channel patch clamp analysis in lung slice preparations, we are able to
uniquely study AT1 and AT2 cells separately from intact lung. We report for the first time the
Na+ transport properties of type 2 cells accessed in live lung tissue (as we have done in type
1 cells). Type 2 cells in lung tissue slices express both highly selective cation and
nonselective cation channels with average conductances of 8.8±3.2 and 22.5±6.3 …
