[HTML][HTML] ATP1AL1, a member of the non-gastric H, K-ATPase family, functions as a sodium pump
AV Grishin, MJ Caplan - Journal of Biological Chemistry, 1998 - ASBMB
The human ATP1AL1-encoded protein (an α subunit of the human non-gastric H, K-ATPase)
has previously been shown to assemble with the gastric H, K-ATPase β subunit (gH, Kβ) to
form a functionally active ionic pump in HEK 293 cells. This pump has been found to be
sensitive to both SCH 28080 and ouabain. However, the 86 Rb+-influx mediated by the
ATP1AL1-gH, Kβ heterodimer in HEK 293 cells is at least 1 order of magnitude larger than
the maximum ouabain-sensitive proton efflux detected in the same cells. In this study we find …
has previously been shown to assemble with the gastric H, K-ATPase β subunit (gH, Kβ) to
form a functionally active ionic pump in HEK 293 cells. This pump has been found to be
sensitive to both SCH 28080 and ouabain. However, the 86 Rb+-influx mediated by the
ATP1AL1-gH, Kβ heterodimer in HEK 293 cells is at least 1 order of magnitude larger than
the maximum ouabain-sensitive proton efflux detected in the same cells. In this study we find …
