Context Although differences in clinical characteristics exist between major depressive
disorder (MDD) and bipolar disorder (BD), consistent structural brain abnormalities that
distinguish the disorders have not been identified. Objectives To investigate structural brain
changes in MDD using meta-analysis of primary studies; assess the effects of medication,
demographic, and clinical variables; and compare the findings with those of a meta-analysis
of studies on BD. Data Sources The MEDLINE, EMBASE, and PsycINFO databases were …